Oni No Kenkyuushitsu ("Laboratory Of The Oni") is a sequel to Oni No Yakata, set 10 years in the future, in the year 2028. You once more play as Ayana Hasegawa as she enters a new job as an intern at Crovich Research Facility, hoping to find a solution to the existence of the Oni that cost her the life of one of her friends, and the lives of many others before them. Little does she know, a combination of poor containment procedures and upper management with ulterior motives will cause the facility to unexpectedly release its specimens and cause chaos.